In vitro comparison of nitrofurazone- and silver alloy-coated foley catheters for contact-dependent and diffusible inhibition of urinary tract infection-associated microorganisms.

Abstract

Two marketed antimicrobial-coated Foley catheters were compared for in vitro diffusible and contact-dependent inhibition of 11 urinary tract infection-associated microorganisms in an adherence-biofilm assay. Nitrofurazone-coated catheters significantly outperformed silver alloy-coated catheters for inhibitory activity, according to both inoculum broth and catheter sonicate counts, whether compared directly or against the corresponding control catheters. Although inhibition waned with catheter preincubation in saline, some organisms were inhibited even after a 48-h catheter preincubation, especially by the nitrofurazone-coated catheter.

• Authors: James R Johnson, Brian Johnston, Michael A Kuskowski
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 56 Issue 9 Pg. 4969-72 (Sep 2012) ISSN: 1098-6596 [Electronic] United States
• PMID: 22751541 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Alloys
• Anti-Infective Agents
• Coated Materials, Biocompatible
• Silver
• Nitrofurazone

Topics

• Alloys (chemistry)
• Anti-Infective Agents (pharmacology)
• Bacterial Adhesion (drug effects)
• Biofilms (drug effects, growth & development)
• Candida albicans (drug effects, growth & development)
• Catheters, Indwelling (microbiology)
• Coated Materials, Biocompatible (pharmacology)
• Gram-Negative Bacteria (drug effects, growth & development)
• Gram-Positive Bacteria (drug effects, growth & development)
• Humans
• Microbial Sensitivity Tests
• Nitrofurazone (pharmacology)
• Silver (chemistry)
• Urinary Catheterization
• Urinary Tract Infections (drug therapy, microbiology, prevention & control)