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Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells.

Abstract
Several lines of experimental data have highlighted a key role of Amadori-glycated phosphatidylethanolamine (Amadori-PE) in the development of diabetic complications. Recent epidemiological studies suggest that diabetes mellitus could be a risk factor for some cancers. A characteristic of cancer cells is their immortal phenotype, and the enzyme telomerase contributes to the infinite replicative potential of cancer cells. The purpose of this study was to obtain new information about the effect of Amadori-PE on the regulation of telomerase in PANC-1 human pancreatic carcinoma cells. Amadori-PE enhanced cellular telomerase in a time- and dose-dependent manner by up-regulating hTERT expression through induction of c-myc. These results provide experimental evidence for a novel role of Amadori-PE in linking diabetes and cancer.
AuthorsTakahiro Eitsuka, Kiyotaka Nakagawa, Yuichi Ono, Naoto Tatewaki, Hiroshi Nishida, Tadao Kurata, Naoki Shoji, Teruo Miyazawa
JournalFEBS letters (FEBS Lett) Vol. 586 Issue 16 Pg. 2542-7 (Jul 30 2012) ISSN: 1873-3468 [Electronic] England
PMID22750441 (Publication Type: Journal Article)
CopyrightCopyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Chemical References
  • Glycolipids
  • Lipids
  • N-(1,6-dideoxyfructopyranosyl)-1,3-dioleoyl-2-phosphatidylethanolamine
  • Phosphatidylethanolamines
  • RNA, Messenger
  • Tetrazolium Salts
  • Thiazoles
  • Telomerase
  • thiazolyl blue
Topics
  • Carcinoma (metabolism)
  • Cell Line, Tumor
  • Disease Progression
  • Dose-Response Relationship, Drug
  • Gene Expression Regulation, Enzymologic
  • Gene Expression Regulation, Neoplastic
  • Glycolipids (pharmacology)
  • Humans
  • Lipids (chemistry)
  • Models, Chemical
  • Pancreatic Neoplasms (metabolism)
  • Phenotype
  • Phosphatidylethanolamines (pharmacology)
  • RNA, Messenger (metabolism)
  • Telomerase (biosynthesis, metabolism)
  • Tetrazolium Salts (pharmacology)
  • Thiazoles (pharmacology)
  • Time Factors
  • Up-Regulation

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