Abstract | AIMS: MAIN METHODS: Eleven healthy males, age 25-30 years participated. The experiment was performed in five sessions on different days between 7 and 8a.m. Session 1, baseline recordings; Session 2, after one night's SD; Session 3, 48 h of recovery from SD; Session 4, after 1 week of Session 1, following one night's SD along with modafinil (400mg/day); Session 5, 48 h of recovery after SD+modafinil. KEY FINDINGS: Subjective sleepiness scores increased significantly after SD as compared to baseline (P<0.01), but remained unaltered after modafinil supplementation. There was an increase in N100 and P300 peak latencies of ERP following SD (P<0.01), which was reduced with modafinil (P<0.05). There was an increase in CNV M100 and P300 peak latencies after SD (P<0.01) which decreased with the use of modafinil (P<0.05). The CNV reaction time increased following SD (P<0.01) and decreased with the use of modafinil (P<0.05). No significant effects on ERP N200, P200 latencies and P200, P300 amplitudes and CNV N100, M200 peak latencies and M100, M200 amplitudes were observed. SIGNIFICANCE:
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Authors | Koushik Ray, Abhirup Chatterjee, Usha Panjwani, Sanjeev Kumar, Surajit Sahu, Sayan Ghosh, Lalan Thakur, Jag Parvesh Anand |
Journal | Life sciences
(Life Sci)
Vol. 91
Issue 3-4
Pg. 94-9
(Aug 21 2012)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 22749868
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Benzhydryl Compounds
- Central Nervous System Stimulants
- Modafinil
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Topics |
- Actigraphy
(methods)
- Adult
- Benzhydryl Compounds
(pharmacology)
- Body Weight
- Central Nervous System Stimulants
(pharmacology)
- Cognition
- Cognition Disorders
(metabolism)
- Electrophysiology
(methods)
- Event-Related Potentials, P300
- Humans
- Male
- Modafinil
- Models, Statistical
- Neurophysiology
(methods)
- Sleep Deprivation
- Surveys and Questionnaires
- Time Factors
- Wakefulness
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