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Management of neutrophilic dermatoses.

Abstract
Neutrophilic dermatoses, including Sweet's syndrome, pyoderma gangrenosum, and rheumatoid neutrophilic dermatitis, are inflammatory conditions of the skin often associated with underlying systemic disease. These are characterized by the accumulation of neutrophils in the skin. The associated conditions, potential for systemic neutrophilic infiltration, and therapeutic management of these disorders can be similar. Sweet's syndrome can often be effectively treated with a brief course of systemic corticosteroids. Pyoderma gangrenosum, however, can be recurrent, and early initiation of a steroid-sparing agent is prudent. Second-line treatment for both of these conditions includes medications affecting neutrophil function, in addition to immunosuppressant medications.
AuthorsCourtney R Schadt, Jeffrey P Callen
JournalDermatologic therapy (Dermatol Ther) 2012 Mar-Apr Vol. 25 Issue 2 Pg. 158-72 ISSN: 1529-8019 [Electronic] United States
PMID22741935 (Publication Type: Journal Article)
Copyright© 2012 Wiley Periodicals, Inc.
Chemical References
  • Glucocorticoids
  • Immunosuppressive Agents
Topics
  • Arthritis, Rheumatoid (complications, pathology)
  • Dermatitis (drug therapy, etiology, pathology)
  • Glucocorticoids (therapeutic use)
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Inflammation (drug therapy, pathology)
  • Neutrophil Infiltration
  • Neutrophils (metabolism)
  • Pyoderma Gangrenosum (drug therapy, pathology)
  • Skin Diseases (drug therapy, pathology)
  • Sweet Syndrome (drug therapy, pathology)

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