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A monoclonal antibody SZ-117 that recognizes filamin A derived from tumor cells.

Abstract
SZ117 is a monoclonal antibody against matrix metalloproteinase-2 (MMP-2) and exhibits anti-tumor angiogenic effect. In this study, we observed that SZ117 bound to a 280 kDa protein, which was detected in tumor cell-derived Matrigel and various tumor cells. Using immunoprecipitation, mass spectrometry analysis, and Western blot analysis, we identified the 280 kDa protein as filamin A and found that filamin A and its degraded products, notably a 53 kDa fragment, were released from a variety of tumor cells. This suggests that SZ117 is useful in the study of the pathogenesis of filamin A and that blockage of filamin A by SZ117 might contribute to the anti-tumor angiogenic effect of the monoclonal antibody.
AuthorsZibin Bu, Ruifang Liu, Bingxue Shang, Zhifei Cao, Yanyan Pan, Quansheng Zhou, Changgeng Ruan
JournalHybridoma (2005) (Hybridoma (Larchmt)) Vol. 31 Issue 3 Pg. 214-8 (Jun 2012) ISSN: 1557-8348 [Electronic] United States
PMID22741587 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Contractile Proteins
  • Filamins
  • Microfilament Proteins
  • Peptide Fragments
  • SZ-117 monoclonal antibody
Topics
  • Amino Acid Sequence
  • Antibodies, Monoclonal (immunology)
  • Contractile Proteins (chemistry, immunology, metabolism)
  • Filamins
  • Humans
  • Microfilament Proteins (chemistry, immunology, metabolism)
  • Molecular Sequence Data
  • Molecular Weight
  • Peptide Fragments (chemistry, immunology, metabolism)
  • Tumor Cells, Cultured

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