Postoperative global amnesia reversed with flumazenil.

Abstract

Global postoperative amnesia (profound anterograde and retrograde amnesia) is rare and usually attributed to transient global amnesia-a poorly understood condition with no broadly accepted mechanism. We report an incident of probable transient global amnesia in a patient after endoscopic retrograde cholangiopancreatogram under general anesthesia, which was successfully treated with flumazenil. On the basis of the results of flumazenil administration in this and a previous case report, we would recommend a trial dose of 0.2 mg for cases of global postoperative amnesia, repeated if the first dose seems effective.

• Authors: Joseph B Rinehart, Brandee Baker, Darren Raphael
• Journal: The neurologist (Neurologist) Vol. 18 Issue 4 Pg. 216-8 (Jul 2012) ISSN: 2331-2637 [Electronic] United States
• PMID: 22735251 (Publication Type: Case Reports, Journal Article)

Chemical References

• Analgesics
• GABA Modulators
• Flumazenil
• Desflurane
• Isoflurane
• Hydromorphone
• Midazolam
• Fentanyl
• Propofol

Topics

• Amnesia (drug therapy, etiology)
• Analgesics (administration & dosage)
• Anesthesia, General (adverse effects)
• Cholangiopancreatography, Endoscopic Retrograde
• Desflurane
• Diabetes Mellitus, Type 2
• Fentanyl (administration & dosage)
• Flumazenil (therapeutic use)
• GABA Modulators (therapeutic use)
• Humans
• Hydromorphone (administration & dosage)
• Isoflurane (administration & dosage, analogs & derivatives)
• Male
• Midazolam (administration & dosage)
• Middle Aged
• Pancreatitis (surgery)
• Postoperative Complications (drug therapy)
• Propofol (administration & dosage)