Abstract | OBJECTIVE: METHODS: Twenty-one patients were divided into three groups. Control group (CG) was treated with the conventional medication for candidiasis ( fluconazole 100 mg/day during 14 days). Laser group (LG) was subjected to low-level laser therapy ( LLLT), wavelength 660 nm, power of 30 mW, and fluence of 7.5 J/cm(2), in contact with mucosa during 10 sec on the affected point. An aPDT group (aPDTG) was treated with aPDT, that is, combination of a low-power laser and methylene blue 450 μg/mL. Pre-irradiation time was 1 min. Parameters of irradiation were the same ones as for the LG, and patients were single irradiated. Patients were clinically evaluated and culture analysis was performed before, immediately after, and 7, 15, and 30 days after the treatment. RESULTS: Our results showed that fluconazole was effective; however, it did not prevent the return of the candidiasis in short-term. LLLT per se did not show any reduction on Candida spp. aPDT eradicated 100% of the colonies of this fungus and the patients did not show recurrence of candidiasis up to 30 days after the irradiation. CONCLUSIONS: These findings suggest that aPDT is a potential approach to oral candidiasis treatment in HIV-infected patients.
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Authors | Agnes Roberta Scwingel, Ana Rita Pinheiro Barcessat, Silvia Cristina Núñez, Martha Simões Ribeiro |
Journal | Photomedicine and laser surgery
(Photomed Laser Surg)
Vol. 30
Issue 8
Pg. 429-32
(Aug 2012)
ISSN: 1557-8550 [Electronic] United States |
PMID | 22730912
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antifungal Agents
- Fluconazole
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Topics |
- AIDS-Related Opportunistic Infections
(drug therapy, radiotherapy)
- Adult
- Antifungal Agents
(therapeutic use)
- Candidiasis, Oral
(drug therapy, radiotherapy)
- Female
- Fluconazole
(therapeutic use)
- Humans
- Low-Level Light Therapy
(methods)
- Male
- Treatment Outcome
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