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Immunization of newborns with bacterial conjugate vaccines.

Abstract
Bacterial conjugate vaccines are based on the principle of coupling immunogenic bacterial capsular polysaccharides to a carrier protein to facilitate the induction of memory T-cell responses. Following the success of Haemophilus influenzae type b conjugate vaccines in the 1980s, conjugate vaccines for Streptococcus pneumoniae and Neisseria meningitidis infections were developed and proven to be effective in protecting children against invasive disease. In this review, the use of conjugate vaccines in human newborns is discussed. Neonatal Haemophilus influenzae type b and pneumococcal conjugate vaccination schedules have been trialed and proven to be safe, with the majority of studies demonstrating no evidence for the induction of immune tolerance. Whether their neonatal administration also results in an earlier induction of clinical protection in the first 2-3 critical months of life is still to be demonstrated.
AuthorsAnita H J van den Biggelaar, William S Pomat
JournalVaccine (Vaccine) Vol. 31 Issue 21 Pg. 2525-30 (May 17 2013) ISSN: 1873-2518 [Electronic] Netherlands
PMID22728221 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2012 Elsevier Ltd. All rights reserved.
Chemical References
  • Bacterial Vaccines
  • Vaccines, Conjugate
Topics
  • Bacterial Vaccines (administration & dosage, immunology)
  • Child
  • Haemophilus influenzae type b (immunology)
  • Humans
  • Infant, Newborn
  • Neisseria meningitidis (immunology)
  • Streptococcus pneumoniae (immunology)
  • Vaccines, Conjugate (administration & dosage, immunology)

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