Epithelioid hemangioendothelioma of the kidney treated with sunitinib.

Abstract

BACKGROUND:

Metastatic epithelioid hemangioendothelioma of the kidney is a rare malignant vascular tumor with a wide spectrum of behaviors.

CASE REPORT:

We present the case of a 53-year-old male patient with tumor metastases which developed after radical nephrectomy. We describe the immunohistochemistry profile of the tumor and the successful long-term results of treatment with sunitinib, a multi-targeted tyrosine kinase inhibitor. Also, we discuss the rationale for using this type of medication based on immunohistochemistry results.

CONCLUSION:

To the best of our knowledge, this is the first reported case of metastatic renal epithelioid hemangioendothelioma treated successfully with sunitinib.

• Authors: Yuri Tolkach, Sergey Petrov, Evelyne Lerut, Hendrik Van Poppel
• Journal: Onkologie (Onkologie) Vol. 35 Issue 6 Pg. 376-8 ( 2012) ISSN: 1423-0240 [Electronic] Switzerland
• PMID: 22722460 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2012 S. Karger AG, Basel.

Chemical References

• Angiogenesis Inhibitors
• Antineoplastic Agents
• Indoles
• Pyrroles
• Sunitinib

Topics

• Angiogenesis Inhibitors (therapeutic use)
• Antineoplastic Agents (therapeutic use)
• Hemangioendothelioma, Epithelioid (diagnosis, drug therapy)
• Humans
• Indoles (therapeutic use)
• Kidney Neoplasms (diagnosis, drug therapy)
• Male
• Middle Aged
• Pyrroles (therapeutic use)
• Sunitinib
• Treatment Outcome