HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A comparison of heparinized low osmolality ionic and nonionic contrast media in 500 patients undergoing cardiac angiography.

Abstract
Low osmolar contrast media (CM) cause less hemodynamic and electrical changes than conventional CM, and many cardiologist have switched to the newer agents. Recently, concerns about a possible increased frequency of thromboembolic complications with low osmolar CM have been raised. This study compared two low osmolar heparinized CM, one ionic (Hexabrix) and the other nonionic (Isovue), in 500 consecutive patients undergoing either diagnostic catheterization (417) or coronary angioplasty (83). Adverse effects were uncommon (37 patients), but were more frequent with Hexabrix (12%) than Isovue (3%); p less than 0.05. The most common adverse effects were nausea or vomiting. Death, related to abrupt occlusion of a severe left main stenosis occurred in one patient who received Hexabrix, and acute pulmonary edema occurred in one patient who received Isovue. No apparent thromboembolic complication occurred. In conclusion, both low osmolar CM were well tolerated, but Hexabrix caused more transient nausea or vomiting. Both CM were safe and the incidence of thromboembolic complications when prospectively looked for was very low.
AuthorsR L Feldman
JournalClinical cardiology (Clin Cardiol) Vol. 13 Issue 11 Pg. 794-6 (Nov 1990) ISSN: 0160-9289 [Print] United States
PMID2272136 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Heparin
  • Iopamidol
  • Ioxaglic Acid
Topics
  • Angiography (adverse effects, methods, mortality)
  • Angioplasty, Balloon, Coronary (methods)
  • Cardiac Catheterization (methods)
  • Heparin (therapeutic use)
  • Humans
  • Iopamidol (adverse effects)
  • Ioxaglic Acid (adverse effects)
  • Osmolar Concentration
  • Thromboembolism (etiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: