Percutaneous sclerotherapy of vascular malformations in children using sodium tetradecyl sulphate: the Birmingham experience.

Abstract

INTRODUCTION AND AIMS:

Sclerotherapy has become first line treatment for most venous malformations and some lymphatic malformations. We aimed to measure our sclerotherapy treatment success using 3% sodium tetradecyl sulphate (STD) and describe our experience.

MATERIALS AND METHODS:

Retrospective five year review (Jan 04-09) of children with vascular malformations treated at our centre with 3% STD. Patients were classified using the Birmingham classification and treatment success was measured through case note review and pre- and post-treatment photographs. FINDINGS AND RESULTS: Forty-three (84.3%) of the 51 patients with vascular malformations (VM) who underwent sclerotherapy derived a benefit. Twelve patients (23.5%) had an excellent result, 31 (60.8%) were improved whilst eight (15.7%) were unchanged. Using Fisher's exact test, there was a statistically significant difference in achieving complete resolution of superficial VMs compared to lesions involving the deeper layers of the head and neck. 17.6% of patients developed a complication with an overall complication rate of 12.2% per injection. There was one major complication with the remainder consisting of superficial skin necrosis that resolved conservatively.

CONCLUSIONS:

Treatment with 3% STD sclerotherapy is effective in venous and some lymphatic vascular malformations. It should be considered an important treatment modality within a multi-disciplinary setting in these difficult problems.

• Authors: Kenneth Kok, Ian McCafferty, Andrew Monaghan, Hiroshi Nishikawa
• Journal: Journal of plastic, reconstructive & aesthetic surgery : JPRAS (J Plast Reconstr Aesthet Surg) Vol. 65 Issue 11 Pg. 1451-60 (Nov 2012) ISSN: 1878-0539 [Electronic] Netherlands
• PMID: 22717975 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Sclerosing Solutions
• Sodium Tetradecyl Sulfate

Topics

• Adolescent
• Arteriovenous Malformations (classification, therapy)
• Child
• Child, Preschool
• Female
• Humans
• Male
• Retrospective Studies
• Sclerosing Solutions (therapeutic use)
• Sclerotherapy (methods)
• Sodium Tetradecyl Sulfate (therapeutic use)
• Treatment Outcome