[Experimental study on effect of dahuang zhechong wan combined with adefovir dipivoxil in preventing hepatic fibrosis in patients with chronic hepatitis B].

Abstract

OBJECTIVE:

To study the changes of experimental markers of hepatic fibrosis in patients with chronic hepatitis B treated by Dahuang Zhechong Wan combined with adefovir dipivoxil.

METHOD:

Ninty and four cases of chronic viral hepatitis B patients were randomly divided into two groups. The treatment group (50 cases) was orally given 10 mg of adefovir dipivoxil once a day, 1 Wan each time, combined with Dahuang Zhechong Wan, 3 times a day, 1 Wan each time. And the control group (44 cases) was treated with adefovir dipivoxil alone, 6 months as a course.

RESULT:

Both the difference of liver fibrosis indexes between the treatment group and the control group and before and after the treatment in the treatment group had statistical significance (P < 0.01 or P < 0.05). Both the difference of experimental markers such as ALT, AST, GGT, TBIL between the treatment group and the control group and before and after the treatment in the treatment group had statistical significance (P < 0.01).

CONCLUSION:

Dahuang Zhechong Wan combined with adefovir dipivoxil could prevent hepatic fibrosis in patients with chronic hepatitis B, reduce the incidence of liver cirrhosis, improve life quality and prognosis.

• Authors: Lijuan Zhang, Yijie Chang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 37 Issue 6 Pg. 862-4 (Mar 2012) ISSN: 1001-5302 [Print] China
• PMID: 22715739 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Antiviral Agents
• Biomarkers
• Drugs, Chinese Herbal
• Organophosphonates
• Adenine
• adefovir dipivoxil

Topics

• Adenine (administration & dosage, analogs & derivatives)
• Administration, Oral
• Adult
• Aged
• Antiviral Agents (administration & dosage)
• Biomarkers (analysis)
• Drug Therapy, Combination
• Drugs, Chinese Herbal (administration & dosage)
• Female
• Hepatitis B, Chronic (complications, drug therapy)
• Humans
• Liver (metabolism)
• Liver Cirrhosis (prevention & control, virology)
• Male
• Middle Aged
• Organophosphonates (administration & dosage)
• Young Adult