[Evaluation of the efficacy of sanguinarine using the experimental gingivitis model].

Abstract

Some studies showed positive results in testing the efficacy of sanguinarine delivered as oral rinse or dentifrice against plaque and gingivitis. The application of a gel containing 0.05 and 0.5% sanguinarine using special trays did not prevent plaque formation in regions with no oral hygiene. In contrast to placebo the 0.5% sanguinaria-gel was able to retard the formation of an experimental gingivitis. Chlorhexidine was superior to sanguinarine. Side effects were not detected.

• Authors: A Kurbad, P Gängler, K Kaufmann
• Journal: Stomatologie der DDR (Stomatol DDR) Vol. 40 Issue 4 Pg. 157-9 (Apr 1990) ISSN: 0302-4725 [Print] Germany
• Vernacular Title: Prüfung von Sanguinaria-Alkaloiden am Modell der experimentellen Gingivitis.
• PMID: 2270564 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Alkaloids
• Benzophenanthridines
• Isoquinolines
• sanguinarine
• Chlorhexidine

Topics

• Adult
• Alkaloids (therapeutic use)
• Benzophenanthridines
• Chlorhexidine (therapeutic use)
• Dental Plaque (prevention & control)
• Gingivitis (therapy)
• Humans
• Isoquinolines