Abstract | BACKGROUND:
Surgical site infections (SSIs) after median sternotomy represent a serious complication and a high potential risk for adverse clinical outcome after cardiac surgery. The antimicrobial skin sealant InteguSeal® was introduced as a novel tool in preventing development of SSI. AIM: This single-centre investigation used two prospective registries to evaluate the prophylactic effect of a cyanoacrylate-based antimicrobial skin sealant (InteguSeal®) on the incidence of postoperative mediastinitis or any other form of chest skin incision SSI after elective cardiac surgery. METHODS: Between October 2010 and April 2011 a total of 998 patients underwent elective cardiac surgical procedures with median sternotomy in our centre. In 496 patients InteguSeal® was included in standard preoperative preparation procedures before chest skin incision (group 1). In 502 patients standard preoperative skin preparation procedures were used without InteguSeal® (group 2). Freedom from mediastinitis and from any other form of SSI within 30 postoperative days were the primary and secondary endpoints, respectively. FINDINGS: A total of 983 patients were eligible for inclusion in per-protocol analysis (488 vs 495 patients). The incidence of postoperative mediastinitis was 2.3% in group 1 vs 3.2% in group 2 (not significant). The incidence of any form of SSI was 10.9% in group 1 vs 11.5% in group 2 (not significant). Perioperative patient characteristics, complexity of surgical procedures performed and length of hospitalization were similar in both groups. CONCLUSION:
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Authors | T Waldow, M Szlapka, J Hensel, K Plötze, K Matschke, L Jatzwauk |
Journal | The Journal of hospital infection
(J Hosp Infect)
Vol. 81
Issue 4
Pg. 278-82
(Aug 2012)
ISSN: 1532-2939 [Electronic] England |
PMID | 22705297
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Anti-Infective Agents, Local
- Cyanoacrylates
- Tissue Adhesives
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Topics |
- Aged
- Anti-Infective Agents, Local
(therapeutic use)
- Cyanoacrylates
(therapeutic use)
- Humans
- Incidence
- Male
- Mediastinitis
(epidemiology, prevention & control)
- Middle Aged
- Skin
- Surgical Wound Infection
(epidemiology, prevention & control)
- Thoracic Surgery
- Tissue Adhesives
(therapeutic use)
- Treatment Outcome
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