In vivo activity of orally administered antibiotics and chemotherapeutics against acute septicaemic pasteurellosis in rabbits.

Abstract

Different antibiotics and chemotherapeutics were tested for therapeutic efficacy in rabbits, in an experimental model using a Pasteurella multocida strain which causes hyperacute septicaemia in this animal species. Only enrofloxacin, administered in the drinking water at a concentration of 50-100 mg/l cured the rabbits, provided that a daily intake of 5 mg/kg body weight was achieved. The other drugs tested (tetracycline, spiramycin, erythromycin and a combination of sulfamerazine with trimethoprim), at doses recommended for rabbits, showed little or no activity at all, with the exception of chloramphenicol, which was only partially effective.

• Authors: L Okerman, L A Devriese, D Gevaert, E Uyttebroek, F Haesebrouck
• Journal: Laboratory animals (Lab Anim) Vol. 24 Issue 4 Pg. 341-4 (Oct 1990) ISSN: 0023-6772 [Print] England
• PMID: 2270044 (Publication Type: Journal Article)

Chemical References

• 4-Quinolones
• Anti-Bacterial Agents
• Anti-Infective Agents
• Fluoroquinolones
• Quinolones
• Enrofloxacin
• Chloramphenicol

Topics

• 4-Quinolones
• Administration, Oral
• Animals
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Anti-Infective Agents (administration & dosage, therapeutic use)
• Chloramphenicol (therapeutic use)
• Drug Evaluation, Preclinical
• Enrofloxacin
• Fluoroquinolones
• Pasteurella Infections (drug therapy, veterinary)
• Quinolones
• Rabbits
• Sepsis (drug therapy, veterinary)