Systemic therapy in the management of metastatic or advanced salivary gland cancers.

Abstract

Salivary gland cancers are very rare tumors. They are characterized by a histologic heterogeneity and a poor outcome. According to this rarity, few prospective data are available to date. No standard recommendations could be held for the use of systemic therapy in these tumors. Several case reports and small studies have investigated the contribution of different agents of chemotherapy. With the extension of molecular biology approach in oncology several signaling pathways have been discovered in different cancers including salivary gland cancers; thus a number of targeted therapies have been investigated. This paper reviewed exhaustively the studies investigating the role of systemic therapies (chemotherapy, targeted therapy, hormone therapy) in salivary gland cancers.

• Authors: Aymen Lagha, Nesrine Chraiet, Mouna Ayadi, Sarra Krimi, Bassem Allani, Hela Rifi, Henda Raies, Amel Mezlini
• Journal: Oral oncology (Oral Oncol) Vol. 48 Issue 10 Pg. 948-957 (Oct 2012) ISSN: 1879-0593 [Electronic] England
• PMID: 22698431 (Publication Type: Journal Article, Review, Retracted Publication)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Antineoplastic Agents, Hormonal

Topics

• Antineoplastic Agents (therapeutic use)
• Antineoplastic Agents, Hormonal (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols
• Carcinoma, Adenoid Cystic (drug therapy)
• Humans
• Molecular Targeted Therapy (methods)
• Neoplasm Metastasis
• Prospective Studies
• Salivary Gland Neoplasms (drug therapy)