The ability of oxime mixtures to increase the reactivating and therapeutic efficacy of antidotal treatment of cyclosarin poisoning in rats and mice.

Abstract

The reactivating and therapeutic efficacy of two combinations ofoximes (HI-6 + trimedoxime and HI-6 + K203) was compared with the effectiveness of antidotal treatment involving single oxime (HI-6, trimedoxime, K203) using in vivo methods. In vivo determined percentage of reactivation of cyclosarin-inhibited blood and tissue acetylcholinesterase in poisoned rats showed that the reactivating efficacy of both combinations of oximes is slightly higher than the reactivating efficacy of the most effective individual oxime in blood, diaphragm as well as in brain. Moreover, both combinations of oximes were found to be slightly more efficacious in the reduction of acute lethal toxic effects in cyclosarin-poisoned mice than the antidotal treatment involving single oxime. Based on the obtained data, we can conclude that the antidotal treatment involving chosen combinations of oximes brings a beneficial effect for its ability to counteract the acute poisoning with cyclosarin.

• Authors: Jirí Kassa, Jana Zdarová Karasová, Růzena Pavlíková, Filip Caisberger, Jirí Bajgar
• Journal: Acta medica (Hradec Kralove) (Acta Medica (Hradec Kralove)) Vol. 55 Issue 1 Pg. 27-31 ( 2012) ISSN: 1211-4286 [Print] Czech Republic
• PMID: 22696932 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene
• Antidotes
• Cholinesterase Reactivators
• Organophosphorus Compounds
• Oximes
• Pyridinium Compounds
• Trimedoxime
• asoxime chloride
• cyclohexyl methylphosphonofluoridate

Topics

• Animals
• Antidotes (therapeutic use)
• Cholinesterase Reactivators (therapeutic use)
• Mice
• Mice, Inbred Strains
• Organophosphorus Compounds (toxicity)
• Oximes (therapeutic use)
• Pyridinium Compounds (therapeutic use)
• Rats
• Rats, Wistar
• Trimedoxime (therapeutic use)