Locked in and out: a case of emerging basilar artery obstruction secondary to vertebral artery dissection thrombolysed with intravenous rt-PA.

The authors present a case in which intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) potentially saved a young man from locked-in syndrome or life threatening consequences. The patient presented with acute stroke secondary to vertebral artery dissection and was treated with intravenous rt-PA. There were no post thrombolysis complications and the patient left hospital with mild neurological symptoms. Our report suggests that in cases of acute posterior circulation stroke due to arterial dissection, treatment with intravenous thrombolysis is safe, practicable and effective.
AuthorsY H Al-Raweshidy, D M Sinha, L J Coward, P C Guyler, A O'Brien
JournalBMJ case reports (BMJ Case Rep) Vol. 2011 ( 2011) ISSN: 1757-790X [Electronic] England
PMID22696744 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Fibrinolytic Agents
  • Tissue Plasminogen Activator
  • Adult
  • Brain Stem Infarctions (diagnosis, etiology)
  • Fibrinolytic Agents (therapeutic use)
  • Humans
  • Male
  • Quadriplegia (prevention & control)
  • Thrombolytic Therapy (methods)
  • Tissue Plasminogen Activator (therapeutic use)
  • Vertebral Artery Dissection (complications, diagnosis)
  • Vertebrobasilar Insufficiency (diagnosis, drug therapy, etiology)

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