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TNF promoter -308 A/G and -238 A/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis.

Abstract
The aim of this study was to determine whether the tumor necrosis factor (TNF) promoter polymorphisms confer susceptibility to juvenile idiopathic arthritis (JIA). A meta-analysis was conducted on the A allele of the TNF -308 A/G and -238 A/G polymorphisms. The nine comparison studies including 1,132 JIA patients and 1,663 controls were included in the meta-analysis and consisted of 7 European, 1 Mexican, and 1 Turkish population. No association was found between JIA and the TNF -308 A allele and the TNF -238 A allele (odds ratio [OR] = 1.211, 95 % confidence interval [CI] = 0.917-1.598, P = 0.177; OR = 1.135, 95 % CI = 0.603-1.861, P = 0.615, respectively). Stratification by ethnicity did not show the association of the TNF -308 and -238 polymorphisms with JIA in Europeans. Mexicans were found to have lower prevalences of A alleles (2.9, 4.1 %) of the TNF -308 A/G and -238 A/G polymorphisms than any other population studied, and the Turkish population the highest (31.2, 26.9 %). This meta-analysis shows no association between the A alleles of the TNF -308 A/G or -238 A/G polymorphisms and JIA in Europeans, but that the prevalences of these alleles are ethnicity dependent.
AuthorsYoung Ho Lee, Sang-Cheol Bae, Gwan Gyu Song
JournalMolecular biology reports (Mol Biol Rep) Vol. 39 Issue 8 Pg. 8497-503 (Aug 2012) ISSN: 1573-4978 [Electronic] Netherlands
PMID22696185 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
Chemical References
  • Tumor Necrosis Factor-alpha
Topics
  • Alleles
  • Arthritis, Juvenile (genetics)
  • Case-Control Studies
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Odds Ratio
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic
  • Tumor Necrosis Factor-alpha (genetics)
  • White People (genetics)

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