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Complete morphologic and molecular remission after introduction of dasatinib in the treatment of a pediatric patient with t-cell acute lymphoblastic leukemia and ABL1 amplification.

Abstract
T-cell acute lymphoblastic leukemia (ALL) accounts for 15% of ALL cases in children and has been associated with a worse prognosis. Cytogenetic studies show an abnormal karyotype in 50-60% of the T-cell ALL patients; ABL1 fusions are present in approximately 8% of the cases. Dasatinib, a second-generation tyrosine kinase inhibitor, directly targets the BCR-ABL gene. We describe a pediatric case of T-cell ALL with amplification of the ABL1 gene in which remission was achieved only after the addition of dasatinib to conventional chemotherapy.
AuthorsOfelia Crombet, Kelly Lastrapes, Arthur Zieske, Jaime Morales-Arias
JournalPediatric blood & cancer (Pediatr Blood Cancer) Vol. 59 Issue 2 Pg. 333-4 (Aug 2012) ISSN: 1545-5017 [Electronic] United States
PMID22689211 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2011 Wiley Periodicals, Inc.
Chemical References
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Thiazoles
  • Proto-Oncogene Proteins c-abl
  • Dasatinib
Topics
  • Child
  • Dasatinib
  • Female
  • Gene Amplification
  • Humans
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (drug therapy, genetics, pathology)
  • Protein Kinase Inhibitors (therapeutic use)
  • Proto-Oncogene Proteins c-abl (genetics)
  • Pyrimidines (therapeutic use)
  • Remission Induction
  • Thiazoles (therapeutic use)

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