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Response to low-dose bortezomib in plasma cell leukemia patients with malignant pleural effusion and ascites: a case report and a review of the literature.

Abstract
Pleural effusion or ascites complicating plasmacytoma is rare and has a poor prognosis. A 70-year-old man was diagnosed as plasma cell leukemia and one course of ranimustine-vindesine, melphalan, and prednisolone followed by melphalan and prednisone (MP) maintained a very good partial response. After MP he was diagnosed to have pleural effusion and ascites as a complication of the plasmacytoma. Low-dose bortezomib caused disappearance of the malignant effusion. The malignant effusions recurred after the end of the second course of bortezomib. High-dose dexamethasone vincristine, doxorubicin, cyclophosphamide, and prednisone yielded no benefit, the patient died of Aspergillus pneumonia.
AuthorsYasunobu Sekiguchi, Syuichi Shirane, Hidenori Imai, Keiji Sugimoto, Mutsumi Wakabayashi, Tomonori Sawada, Noriko Chigira, Kunimoto Ichikawa, Norio Komatsu, Masaaki Noguchi
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 51 Issue 11 Pg. 1393-8 ( 2012) ISSN: 1349-7235 [Electronic] Japan
PMID22687849 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Antineoplastic Agents
  • Boronic Acids
  • Pyrazines
  • Bortezomib
  • Melphalan
  • Prednisone
Topics
  • Aged
  • Antineoplastic Agents (administration & dosage)
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
  • Ascites (drug therapy, etiology)
  • Boronic Acids (administration & dosage)
  • Bortezomib
  • Fatal Outcome
  • Humans
  • Leukemia, Plasma Cell (complications, drug therapy)
  • Male
  • Melphalan (administration & dosage)
  • Pleural Effusion, Malignant (drug therapy, etiology)
  • Prednisone (administration & dosage)
  • Pyrazines (administration & dosage)
  • Treatment Failure

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