Poor outcome of myeloablative conditioned allogeneic bone marrow transplantation for myelofibrosis.

Abstract

OBJECTIVE:

This study retrospectively analyzed clinical outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for myelofibrosis (MF) in a single institution.

METHODS:

During the past 20 years, 6 patients with MF have undergone allo-HSCT in our institution. We investigated the clinical characteristics and follow-up course of these patients.

PATIENTS:

Median age was 47 years (range, 40-52 years). The median interval between diagnosis and allo-HSCT was 12.5 months (range, 5-97 months).

RESULTS:

Among these 6 patients, 4 patients were categorized in the high-risk group according to the International Prognostic Scoring System. All 6 patients received myeloablative conditioning regimens, but most of them eventually died of relapse.

CONCLUSION:

In this small series, allo-HSCT resulted in dismal outcomes. Our experience clearly indicates the need for studies with a larger series of patients to evaluate the efficacy of this modality.

• Authors: Masahide Yamamoto, Kazuteru Ohashi, Yuka Hirashima, Takeshi Kobayashi, Kazuhiko Kakihana, Hideki Akiyama, Hisashi Sakamaki
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 51 Issue 10 Pg. 1183-6 ( 2012) ISSN: 1349-7235 [Electronic] Japan
• PMID: 22687787 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Female
• Hematopoietic Stem Cell Transplantation
• Humans
• Male
• Middle Aged
• Primary Myelofibrosis (therapy)
• Recurrence
• Retrospective Studies
• Risk Factors
• Transplantation Conditioning
• Transplantation, Homologous
• Treatment Outcome