[Microdialysis study of release of adenine nucleotide breakdown products into the intercellular space of the myocardium in ischemia and reperfusion].

Abstract

Interstitial concentrations of adenine nucleotide breakdown products (ANBP)--adenosine (ADS), inosine (INS), hypoxanthine (HYP), in perfused rat hearts were measured during total ischemia and reperfusion by microdialysis technique. Progressive accumulation of ANBP in the interstitial space was observed during ischemia, but unlike INS and HYP, maximal ADS concentration was reached not by the end of ischemia but after the beginning of reperfusion. During reperfusion the qualitative accordance between changes in ANBP levels in the interstitial space and venous effluent was observed, but interstitial concentrations were several times greater.

• Authors: A I Kuz'min, V S Shul'zhenko, V N Selivanov, T V Saprygina, O S Medvedev, V I Kapel'ko
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 110 Issue 9 Pg. 278-80 (Sep 1990) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Mikrodializnoe issledovanie vysvobozhdeniia v mezhkletochnoe prostranstvo miokarda produktov raspada adeninnukleotidov pri ishemii i reperfuzii.
• PMID: 2268714 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adenine Nucleotides
• Hypoxanthines
• Hypoxanthine
• Inosine
• Adenosine

Topics

• Adenine Nucleotides (metabolism)
• Adenosine (metabolism)
• Animals
• Dialysis
• Extracellular Space (metabolism)
• Hypoxanthine
• Hypoxanthines (metabolism)
• Inosine (metabolism)
• Male
• Myocardial Infarction (metabolism)
• Myocardial Reperfusion
• Myocardium (metabolism)
• Rats
• Rats, Inbred Strains