Abstract |
In the present study, we investigated the roles of TGF-β signaling pathway in a rat benign prostatic hyperplasia (BPH) model treated with cetrorelix. TGF-β1 and c-Myc expression were measured by qRT-PCR and Western blotting in the proximal and distal region of ventral prostatic lobes, respectively. We observed that treatment with cetrorelix led to a significant reduction of ventral prostate weight in a dose-dependent manner. In the proximal region, after cetrorelix treatment, the expression of TGF-β1 was dramatically increased (P<0.05), while the expression of c-Myc was significantly decreased (P<0.05). In comparison with the control group, the cetrorelix groups had more TUNEL-positive cells. Our findings strongly suggest that the TGF-β signaling pathway may be one of the major causes responsible for prostate volume reduction in BPH rats after cetrorelix treatment.
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Authors | Dong Yang, Teng Hou, Xiong Yang, Yan Ma, Longwang Wang, Bing Li |
Journal | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
(J Huazhong Univ Sci Technolog Med Sci)
Vol. 32
Issue 3
Pg. 389-395
(Jun 2012)
ISSN: 1672-0733 [Print] China |
PMID | 22684563
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hormone Antagonists
- Proto-Oncogene Proteins c-myc
- Transforming Growth Factor beta1
- Gonadotropin-Releasing Hormone
- cetrorelix
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Topics |
- Animals
- Atrophy
(pathology, physiopathology)
- Disease Models, Animal
- Gonadotropin-Releasing Hormone
(analogs & derivatives, antagonists & inhibitors)
- Hormone Antagonists
- Humans
- Male
- Organ Size
(drug effects)
- Prostatic Hyperplasia
(chemically induced, pathology, physiopathology)
- Proto-Oncogene Proteins c-myc
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Transforming Growth Factor beta1
(metabolism)
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