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Mechanisms of prostate atrophy after LHRH antagonist cetrorelix injection: an experimental study in a rat model of benign prostatic hyperplasia.

Abstract
In the present study, we investigated the roles of TGF-β signaling pathway in a rat benign prostatic hyperplasia (BPH) model treated with cetrorelix. TGF-β1 and c-Myc expression were measured by qRT-PCR and Western blotting in the proximal and distal region of ventral prostatic lobes, respectively. We observed that treatment with cetrorelix led to a significant reduction of ventral prostate weight in a dose-dependent manner. In the proximal region, after cetrorelix treatment, the expression of TGF-β1 was dramatically increased (P<0.05), while the expression of c-Myc was significantly decreased (P<0.05). In comparison with the control group, the cetrorelix groups had more TUNEL-positive cells. Our findings strongly suggest that the TGF-β signaling pathway may be one of the major causes responsible for prostate volume reduction in BPH rats after cetrorelix treatment.
AuthorsDong Yang, Teng Hou, Xiong Yang, Yan Ma, Longwang Wang, Bing Li
JournalJournal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban (J Huazhong Univ Sci Technolog Med Sci) Vol. 32 Issue 3 Pg. 389-395 (Jun 2012) ISSN: 1672-0733 [Print] China
PMID22684563 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Hormone Antagonists
  • Proto-Oncogene Proteins c-myc
  • Transforming Growth Factor beta1
  • Gonadotropin-Releasing Hormone
  • cetrorelix
Topics
  • Animals
  • Atrophy (pathology, physiopathology)
  • Disease Models, Animal
  • Gonadotropin-Releasing Hormone (analogs & derivatives, antagonists & inhibitors)
  • Hormone Antagonists
  • Humans
  • Male
  • Organ Size (drug effects)
  • Prostatic Hyperplasia (chemically induced, pathology, physiopathology)
  • Proto-Oncogene Proteins c-myc (metabolism)
  • Rats
  • Rats, Sprague-Dawley
  • Transforming Growth Factor beta1 (metabolism)

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