Compensated inflammation in systemic juvenile idiopathic arthritis: role of alternatively activated macrophages.

Abstract

To investigate the role of alternative activation of macrophages, in particular, the role of the CD163/HO-1 axis in systemic juvenile idiopathic arthritis (s-JIA), we serially examined the concentrations of HO-1, sCD163 and pro-inflammatory cytokines (IL-10, IL-18, IL-6, neopterin, soluble TNF-α receptor types I and II) in patients with s-JIA complicated by macrophage activation syndrome (MAS/s-JIA). Serum concentrations of HO-1, sCD163 and IL-10 in s-JIA patients were markedly elevated in the active phase including MAS and correlated positively with indicators for s-JIA disease activity. Serum concentrations of HO-1, sCD163 and IL-10, as well as IL-18, remained elevated in s-JIA patients even in the inactive phase of disease, whereas clinical parameters and other pro-inflammatory cytokines normalized. These findings indicate that alternative macrophage activation plays an important role not only in the active phase but also in the inactive phase of s-JIA. These findings suggest that the inactive phase of s-JIA represents a state of compensated inflammation rather than absence of immune activity.

• Authors: Masaki Shimizu, Akihiro Yachie
• Journal: Cytokine (Cytokine) Vol. 60 Issue 1 Pg. 226-32 (Oct 2012) ISSN: 1096-0023 [Electronic] England
• PMID: 22682876 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Antigens, CD
• Antigens, Differentiation, Myelomonocytic
• CD163 antigen
• Interleukin-18
• Interleukin-6
• Receptors, Cell Surface
• Receptors, Tumor Necrosis Factor
• Interleukin-10
• Neopterin
• HMOX1 protein, human
• Heme Oxygenase-1

Topics

• Adolescent
• Antigens, CD (blood)
• Antigens, Differentiation, Myelomonocytic (blood)
• Arthritis, Juvenile (blood, complications)
• Child
• Child, Preschool
• Enzyme-Linked Immunosorbent Assay
• Female
• Heme Oxygenase-1 (blood)
• Humans
• Infant
• Inflammation (blood, complications)
• Interleukin-10 (blood)
• Interleukin-18 (blood)
• Interleukin-6 (blood)
• Macrophage Activation
• Macrophage Activation Syndrome (blood, complications)
• Macrophages (metabolism)
• Male
• Neopterin (blood)
• Receptors, Cell Surface (blood)
• Receptors, Tumor Necrosis Factor (blood)
• Time Factors