Disseminated juvenile xanthogranuloma associated with follicular lymphoma in an adult: successful treatment with chemotherapy and rituximab. A review of the literature.

Abstract

Juvenile xanthogranuloma is a non-Langerhans cell histiocytosis that typically affects children, but several cases have been reported in adults, some in connection with hematologic malignancies. We present the case of a 61-year-old woman with multiple xanthogranulomas who developed a follicular lymphoma after 4 years of follow-up. After 6 months of treatment with chemotherapy and rituximab, the cutaneous lesions disappeared and the patient achieved remission from lymphoma. We highlight this case because xanthogranuloma is a rare disorder that is difficult to diagnose in adults and also because this is the first report of an association between xanthogranuloma and follicular lymphoma. Excellent response was achieved with chemotherapy and rituximab. Finally, given the possible association between xanthogranulomas and hematologic diseases, these lesions may be a cutaneous manifestation of an occult malignancy.

• Authors: B Narváez-Moreno, Á Pulpillo-Ruiz, T De Zulueta-Dorado, J Conejo-Mir
• Journal: Actas dermo-sifiliograficas (Actas Dermosifiliogr) Vol. 104 Issue 3 Pg. 242-6 (Apr 2013) ISSN: 1578-2190 [Electronic] Spain
• PMID: 22681714 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: Copyright © 2011 Elsevier España, S.L. and AEDV. All rights reserved.

Chemical References

• Antibodies, Monoclonal, Murine-Derived
• Antineoplastic Agents
• Rituximab

Topics

• Antibodies, Monoclonal, Murine-Derived (therapeutic use)
• Antineoplastic Agents (therapeutic use)
• Female
• Humans
• Lymphoma, Follicular (complications, drug therapy)
• Middle Aged
• Remission Induction
• Rituximab
• Xanthogranuloma, Juvenile (complications, drug therapy)