Timing of hepatitis B vaccination and impact of non-simultaneous vaccination with DTP vaccine following introduction of a hepatitis B birth dose in the Philippines.

Timely administration of hepatitis B vaccine beginning at birth prevents up to 95 per cent of perinatally acquired hepatitis B virus infections in infants of infected mothers. The Philippines changed its national HepB schedule in 2007 to include a dose at birth. We evaluated vaccination schedule change by reviewing infant records at selected health facilities to measure completeness and timeliness of HepB administration and frequency of recommended, simultaneous vaccination with diphtheria-tetanus-pertussis (DTP) vaccine. Of 1431 sampled infants, 1106 (77 per cent) completed the HepB series and 10 per cent followed the national schedule. The proportion with timely vaccination declined with successive doses: HepB1 (71 per cent), HepB2 (47 per cent), and HepB3 (26 per cent). Twentysix per cent received HepB2 simultaneously with DTP1 and 34 per cent received HepB3 simultaneously with DTP3. If HepB and DTP vaccination were given simultaneously,10 per cent more infants could have received all HepB doses. Program implementers should monitor vaccination timeliness and increase simultaneous administration to improve vaccination coverage and decrease disease incidence.
AuthorsAaron S Wallace, Howard Sobel, Tove K Ryman, Jacinto Blas Mantaring 3rd, Mianne Silvestre, Margaret Thorley, Joyce Ducusin, Soe Nyunt-U
JournalJournal of public health policy (J Public Health Policy) Vol. 33 Issue 3 Pg. 368-81 (Aug 2012) ISSN: 1745-655X [Electronic] England
PMID22673757 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Hepatitis B Vaccines
  • Chi-Square Distribution
  • Diphtheria-Tetanus-Pertussis Vaccine (administration & dosage)
  • Female
  • Guideline Adherence
  • Hepatitis B (prevention & control)
  • Hepatitis B Vaccines (administration & dosage)
  • Humans
  • Immunization Programs
  • Immunization Schedule
  • Infant
  • Infant, Newborn
  • Male
  • Philippines
  • Time Factors

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