Ifosfamide induced Fanconi syndrome.

Abstract

Ifosfamide (IFA) is a powerful chemotherapeutic drug that is active against a variety of paediatric malignancies. However, renal toxicities such as haemorrhagic cystitis and Fanconi syndrome are major hazards that hinder its use in clinical practice. The authors present a case of a patient treated for Wilms' tumour with IFA who developed rickets with Fanconi syndrome. Patients undergoing IFA treatment must be carefully monitored for the development of iatrogenic complications. Recent studies have improved our understanding of the underlying pathomechanism of IFA induced Fanconi syndrome, and selective renal protection against during chemotherapy with IFA may be possible soon.

• Authors: Samantha Buttemer, Mohan Pai, Keith K Lau
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2011 (Dec 20 2011) ISSN: 1757-790X [Electronic] England
• PMID: 22669992 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Alkylating
• Ifosfamide

Topics

• Antineoplastic Agents, Alkylating (adverse effects)
• Child, Preschool
• Fanconi Syndrome (chemically induced)
• Humans
• Ifosfamide (adverse effects)
• Male