Amlexanox is as effective as dexamethasone in topical treatment of erosive oral lichen planus: a short-term pilot study.

Abstract

OBJECTIVE:

The objective of this study was to evaluate the efficacy and safety of short-term and topical application of amlexanox paste in the treatment of erosive oral lichen planus (EOLP).

STUDY DESIGN:

A randomized, positive-controlled clinical trial was conducted from September 1 to December 31, 2009. Thirty-eight patients with EOLP received amlexanox paste (n = 20) or dexamethasone paste (n = 18) for 7 days. Outcome measures included size of erosive area and visual analog scale (VAS) scores.

RESULTS:

After 7 days of treatment, both groups showed significant reduction in erosive area and VAS scores (P < .001). There was no difference between groups in the reduction of erosive area (P = .937) and VAS scores (P = .161). None of the patients had severe adverse reactions.

CONCLUSIONS:

Topical application of amlexanox appeared as effective as dexamethasone in the treatment of EOLP and no serious side effects were found in this pilot study.

• Authors: Ji Fu, Xiaohan Zhu, Hongxia Dan, Yu Zhou, Chuanxia Liu, Fang Wang, Yanzhong Li, Na Liu, Qianming Chen, Yi Xu, Xin Zeng, Lu Jiang
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 113 Issue 5 Pg. 638-43 (May 2012) ISSN: 2212-4411 [Electronic] United States
• PMID: 22668622 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Aminopyridines
• Anti-Allergic Agents
• Anti-Inflammatory Agents
• Dexamethasone
• amlexanox

Topics

• Administration, Topical
• Adult
• Aged
• Aminopyridines (therapeutic use)
• Anti-Allergic Agents (administration & dosage)
• Anti-Inflammatory Agents (administration & dosage)
• Dexamethasone (therapeutic use)
• Female
• Humans
• Lichen Planus, Oral (drug therapy)
• Male
• Middle Aged
• Pilot Projects
• Prospective Studies
• Statistics, Nonparametric
• Treatment Outcome
• Young Adult