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Effect of salivary stimulation therapies on salivary flow and chemotherapy-induced mucositis: a preliminary study.

AbstractOBJECTIVE:
The objective of this study was to evaluate the effect of salivary stimulation therapies on the salivary flow, oral mucositis, and salivary cytokine levels in patients receiving allogeneic hematopoietic stem cell transplantation.
STUDY DESIGN:
Thirty-five eligible patients were randomized into 4 groups: control, mechanical sialogogue, transcutaneous electrical nerve stimulation (TENS) sialogogue, and combined mechanical/electrical sialogogue. Saliva was collected from patients before transplantation and at days 3, 7, and 14 after transplantation. The volume was measured and salivary cytokines were assessed using enzyme-linked immunosorbent assay.
RESULTS:
By day 14, resting and stimulated salivary flow levels were diminished. Resting salivary flow rates decreased the most in the control and mechanical groups. In contrast, TENS alone or in combination with mechanical stimulatory therapy benefited the patients. TENS-treated patients showed increase in resting salivary flow. Also, the groups treated with TENS had fewer patients affected by grades 3 and 4 mucositis, and less mucositis was associated with better patient survival (P = .027).
CONCLUSIONS:
TENS-associated salivary stimulation therapies minimized the reduction of salivary flow and prevented severe chemotherapy-induced oral mucositis.
AuthorsTânia Mara Pimenta Amaral, Camila Cláudia Campos, Tálita Pollyanna Moreira dos Santos, Cláudio Rodrigues Leles, Antônio Lúcio Teixeira, Mauro Martins Teixeira, Henrique Bittencourt, Tarcília Aparecida Silva
JournalOral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 113 Issue 5 Pg. 628-37 (May 2012) ISSN: 2212-4411 [Electronic] United States
PMID22668621 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Inc. All rights reserved.
Chemical References
  • Tissue Inhibitor of Metalloproteinase-1
  • Tumor Necrosis Factor-alpha
  • Tissue Inhibitor of Metalloproteinase-2
  • Interleukin-10
  • Epidermal Growth Factor
  • MMP2 protein, human
  • Matrix Metalloproteinase 2
  • Matrix Metalloproteinase 9
Topics
  • Adult
  • Analysis of Variance
  • Epidermal Growth Factor (analysis)
  • Female
  • Hematopoietic Stem Cell Transplantation (adverse effects)
  • Humans
  • Interleukin-10 (analysis)
  • Male
  • Matrix Metalloproteinase 2 (analysis)
  • Matrix Metalloproteinase 9 (analysis)
  • Middle Aged
  • Mucositis (chemically induced)
  • Physical Stimulation
  • Prospective Studies
  • Saliva (chemistry, metabolism)
  • Salivation (drug effects)
  • Statistics, Nonparametric
  • Stomatitis (chemically induced)
  • Tissue Inhibitor of Metalloproteinase-1 (analysis)
  • Tissue Inhibitor of Metalloproteinase-2 (analysis)
  • Transcutaneous Electric Nerve Stimulation
  • Transplantation Conditioning (adverse effects)
  • Tumor Necrosis Factor-alpha (analysis)
  • Young Adult

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