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[Neuroprotective effect of baicalein in patients with Parkinson's disease].

Abstract
Baicalein, a flavonoid compound extracted from dried roots of traditional Chinese medicine Scutellaria baicalensis, has been widely applied as an antioxidant and anti-inflammatory agent. With continuous studies on its mechanisms, recent findings suggest that baicalein has some effect on neuroprotection and improvement of clinical symptoms in neurodegenerative diseases such as Parkinson's disease. Recent studies showed that its neuroprotective efficacy is closely related to such functions as antiinflammatory, antioxidative stress, protecting chondriosome, inhibiting glutamate neurotoxicity, promoting nerve growth and inhibiting alpha-synuclein protein-aggregate activities. The aim of this article is to summarize the neuroprotective effects of baicalein in Parkinson's disease.
AuthorsXin Yu, Guorong He, Guanhua Du
JournalZhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 37 Issue 4 Pg. 421-5 (Feb 2012) ISSN: 1001-5302 [Print] China
PMID22667137 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Flavanones
  • Neuroprotective Agents
  • baicalein
  • Nerve Growth Factor
Topics
  • Flavanones (pharmacology, therapeutic use)
  • Humans
  • Mitochondria (drug effects, metabolism)
  • Nerve Growth Factor (metabolism)
  • Neuroprotective Agents (pharmacology, therapeutic use)
  • Oxidative Stress (drug effects)
  • Parkinson Disease (drug therapy, metabolism, pathology)

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