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Parathyroid hormone: an early predictor of symptomatic hypocalcemia after total thyroidectomy.

AbstractOBJECTIVE:
The purpose of this study was to evaluate if the measurement of peri-operative parathyroid hormone (PTH) is able to identify patients with increased risk of developing symptoms of hypocalcemia.
SUBJECTS AND METHODS:
Forty patients who underwent total thyroidectomy were studied prospectively. Ionized serum calcium and PTH were measured after induction of anesthesia, one hour (PTH1) and one day after surgery (PTH24). Patients were evaluated for symptoms of hypocalcemia and treated with calcium and vitamin D supplementation as necessary.
RESULTS:
Symptomatic hypocalcemia developed in 16 patients. Symptomatic patients had significant lower PTH1 and greater drops in PTH levels. The selection of 12.1 ng/L as PTH1 level cutoff level divided patients with and without symptoms with 93.7% sensitivity and 91.6% specificity. The selection of 73.5% as the cutoff value for PTH decrease resulted in 91.6% sensitivity and 87.5% specificity.
CONCLUSION:
PTH1 levels and the drop in PTH levels are reliable predictors of developing symptomatic hypocalcemia after total thyroidectomy.
AuthorsFelipe Augusto Brasileiro Vanderlei, Jose Gilberto Henriques Vieira, Flavio Carneiro Hojaij, Onivaldo Cervantes, Ilda Sizue Kunii, Monique Nakayama Ohe, Rodrigo Oliveira Santos, Marcio Abrahão
JournalArquivos brasileiros de endocrinologia e metabologia (Arq Bras Endocrinol Metabol) Vol. 56 Issue 3 Pg. 168-72 (Apr 2012) ISSN: 1677-9487 [Electronic] Brazil
PMID22666731 (Publication Type: Journal Article)
Chemical References
  • Biomarkers
  • Parathyroid Hormone
  • Vitamins
  • Vitamin D
  • Calcium
Topics
  • Biomarkers (blood)
  • Calcium (administration & dosage, blood)
  • Female
  • Humans
  • Hypocalcemia (diagnosis, etiology, therapy)
  • Male
  • Middle Aged
  • Parathyroid Glands
  • Parathyroid Hormone (blood)
  • Predictive Value of Tests
  • Preoperative Care
  • Prospective Studies
  • Risk
  • Thyroidectomy (adverse effects)
  • Vitamin D (administration & dosage)
  • Vitamins (administration & dosage)

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