Ulceration of mouth mucosa is frequently occurs after
injuries in oral cavity.
Oral ulcers are relatively common and these lesions cause strong
pain and discomfort. Frequently, injury of the oral tissues results in abnormal fibroblast activation and
keloid formation. This pathological
scar formation is often associates with
pain and malfunction of the organ. To understand these phenomena and develop effective treatment, reproducible animal models have to be introduced. Athymic nude mice where used to create animal models. 1% HCl
acid solution was used for chemical damage of the mucosa tissue. Surgical operation was performed to create traumatic injury in the mouse oral cavity. Tissues were analyzed using immunohistochemistry methods. All of the HCl treated animals developed
ulcers on the skin and mucosa of the oral cavity. Most of the mice on the place of
surgical wound developed
keloid tissue. Mice in which we induced
pathological processes of the oral tissue, did not gain
body weight. Moreover their mass had tendency to decrease. Hematoxilyn-
eosin staining of the ulcerated mice tissues revealed extended coagulation
necrosis - covering all tissue layers of the oral cavity. Strong local inflammatory cell infiltration and absence of proliferative cells has been demonstrated in these ulcerated and adjusted oral tissues. Morphological analysis of
scar tissue revealed fibrotic
hypertrophy of the injured oral tissues in these animals with the expressed infiltration of inflammatory cells. Our animal models reflect morphology of the specific injury and functionally imitate the disease.