Efficacy of mosapride citrate with polyethylene glycol solution for colonoscopy preparation.

Abstract

AIM:

To evaluate the efficacy and safety of adjunctive mosapride citrate for bowel preparation before colonoscopy.

METHODS:

We conducted a randomized, double-blind, placebo-controlled study with mosapride in addition to polyethylene glycol (PEG)-electrolyte solution. Of 250 patients undergoing colonoscopy, 124 were randomized to receive 2 L PEG plus 15 mg of mosapride citrate (mosapride group), and 126 received 2 L PEG plus placebo (placebo group). Patients completed a questionnaire reporting the acceptability and tolerability of the bowel preparation process. The efficacy of bowel preparation was assessed by colonoscopists using a 5-point scale based on Aronchick's criteria. The primary end point was optimal bowel preparation rates (scores of excellent/good/fair vs poor/inadequate).

RESULTS:

A total of 249 patients were included in the analysis. In the mosapride group, optimal bowel preparation rates were significantly higher in the left colon compared with the placebo group (78.2% vs 65.6%, P < 0.05), but not in the right colon (76.5% vs 66.4%, P = 0.08). After excluding patients with severe constipation, there was a significant difference in bowel preparation in both the left and right colon (82.4% vs 66.7%, 80.8% vs 67.5%, P < 0.05, P < 0.01). The incidence of adverse events was similar in both groups. Among the subgroup who had previous colonoscopy experience, a significantly higher number of patients in the mosapride group felt that the current preparation was easier compared with patients in the placebo group (34/72 patients vs 24/74 patients, P < 0.05).

CONCLUSION:

Mosapride citrate may be an effective and safe adjunct to PEG-electrolyte solution that leads to improved quality of bowel preparation, especially in patients without severe constipation.

• Authors: Masahiro Tajika, Yasumasa Niwa, Vikram Bhatia, Hiroki Kawai, Shinya Kondo, Akira Sawaki, Nobumasa Mizuno, Kazuo Hara, Susumu Hijioka, Kazuya Matsumoto, Yuji Kobayashi, Akira Saeki, Asana Akabane, Koji Komori, Kenji Yamao
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 18 Issue 20 Pg. 2517-25 (May 28 2012) ISSN: 2219-2840 [Electronic] United States
• PMID: 22654449 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Benzamides
• Cathartics
• Morpholines
• Serotonin Receptor Agonists
• Polyethylene Glycols
• mosapride

Topics

• Aged
• Benzamides (administration & dosage, adverse effects)
• Cathartics (administration & dosage, adverse effects)
• Colonoscopy (methods)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Morpholines (administration & dosage, adverse effects)
• Patient Compliance
• Polyethylene Glycols (administration & dosage, adverse effects)
• Serotonin Receptor Agonists (administration & dosage, adverse effects)
• Surveys and Questionnaires