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Vitamin K status in patients with short bowel syndrome.

AbstractBACKGROUND & AIMS:
Available evidence suggests that patients with short bowel syndrome (SBS) might be at risk of vitamins A, D, E and B(1) deficiency. However, there is little clinical data describing the vitamin K status. Therefore, in the present study we aimed to assess the body resources of vitamin K in a subset of SBS patients.
METHODS:
The study comprised 33 patients aged 1 month to 16 years. PIVKA-II concentrations were determined in all subjects.
RESULTS:
In all studied subjects, coagulation parameters were normal. PIVKA-II levels indicative of vitamin K deficiency was found in 3 (9.1%) SBS patients. One patient had been receiving an additional intravenous vitamin K dose of 5 mg/week. In all SBS patients with cirrhosis and cholestasis, PIVKA-II concentrations were low (<2 ng/ml). However, all patients with severe liver disease were receiving vitamin K several times a month.
CONCLUSIONS:
Vitamin K deficiency may appear in SBS patients.
AuthorsPatrycja Krzyżanowska, Janusz Książyk, Małgorzata Kocielińska-Kłos, Elżbieta Banaś, Małgorzata Kaleta, Katarzyna Popińska, Tomasz Szczapa, Jarosław Walkowiak
JournalClinical nutrition (Edinburgh, Scotland) (Clin Nutr) Vol. 31 Issue 6 Pg. 1015-7 (Dec 2012) ISSN: 1532-1983 [Electronic] England
PMID22633417 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012. Published by Elsevier Ltd.
Chemical References
  • Antifibrinolytic Agents
  • Biomarkers
  • Protein Precursors
  • Vitamins
  • Vitamin K
  • acarboxyprothrombin
  • Prothrombin
Topics
  • Adolescent
  • Antifibrinolytic Agents (administration & dosage, blood)
  • Biomarkers (blood)
  • Blood Coagulation
  • Child
  • Child, Preschool
  • Cholestasis (blood)
  • Female
  • Humans
  • Infant
  • Liver Cirrhosis (blood)
  • Male
  • Protein Precursors (blood)
  • Prothrombin
  • Short Bowel Syndrome (blood, complications)
  • Vitamin K (administration & dosage, blood)
  • Vitamin K Deficiency (complications, diagnosis)
  • Vitamins (administration & dosage, blood)

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