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Expression and prognostic value of matrix metalloproteinase-7 in colorectal cancer.

Abstract
The purpose of this study was to evaluate expression and prognostic value of matrix metalloproteinase-7 (MMP-7) in colorectal cancer (CRC) patients. CRC tissues and corresponding distal normal mucosa tissues of 118 CRC patients were assessed by immunohistochemistry. Correlations between MMP-7 expression, patients' clinic pathological features, and overall survival rate were analyzed. We found that positive expression of MMP- 7 in CRC tissues was significantly higher than that in distal normal mucosa (61.0% vs. 39.8%, p=0.001). Poor histological differentiation, advanced clinical stage and lymph node metastasis were significantly correlated with MMP-7 expression in CRC. The overall survival rate was significantly higher in the MMP-7 negative group than the positive group (Log-rank test=9.957, p=0.002). MMP-7 appeared as a significant independent prognostic factor through multivariate survival analysis. Collectively, we found MMP-7 expression to be correlated with progression and metastasis of CRC and thus could be used as a predictive marker of prognosis in CRC patients.
AuthorsBo Yang, Ke Su, Jianfei Gao, Zhiguo Rao
JournalAsian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 13 Issue 3 Pg. 1049-52 ( 2012) ISSN: 1513-7368 [Print] Thailand
PMID22631636 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Matrix Metalloproteinase 7
Topics
  • Adult
  • Aged
  • Biomarkers, Tumor
  • Colorectal Neoplasms (metabolism, mortality, pathology)
  • Female
  • Humans
  • Immunohistochemistry
  • Kaplan-Meier Estimate
  • Lymphatic Metastasis
  • Male
  • Matrix Metalloproteinase 7 (metabolism)
  • Middle Aged
  • Neoplasm Staging
  • Prognosis
  • Proportional Hazards Models
  • Survival Rate

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