Abstract | OBJECTIVE: To evaluate the possible correlation between the extent of sclerotic glomeruli and the level of serum creatinine and its clearance rate in patients with primary focal segmental glomerolusclerosis. MATERIAL AND METHOD: In a cross-sectional study, 50 patients with biopsy-proven primary focal segmental glomerolusclerosis were recruited. The proportion of globally and segmentally sclerosed glomeruli was determined during the first histopathological examination of renal biopsy specimens. Correlations of these variables with on admission serum level of creatinine and its clearance rate were investigated. RESULTS: Twenty-four males and 26 females with a mean age of 39.82±16.45 (range: 16-85) years were enrolled in the study. In a significant fashion, the proportions of segmental and global glomerulosclerosis were directly correlated with the serum level of creatinine and inversely with its clearance rate (r=-0.43 with p=0.002 and r=-0.45 with p=0.001, respectively). CONCLUSION:
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Authors | Ashraf Fakhrjou, Ahad Hashempour, Sepideh Shadravan, Rohollah Fadaei Fouladi |
Journal | Turk patoloji dergisi
(Turk Patoloji Derg)
Vol. 28
Issue 2
Pg. 104-9
( 2012)
ISSN: 1309-5730 [Electronic] Turkey |
PMID | 22627627
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Biopsy
- Chi-Square Distribution
- Creatinine
(blood)
- Cross-Sectional Studies
- Female
- Glomerulosclerosis, Focal Segmental
(blood, diagnosis, pathology, physiopathology)
- Humans
- Iran
- Kidney Function Tests
- Kidney Glomerulus
(pathology, physiopathology)
- Male
- Middle Aged
- Predictive Value of Tests
- Prognosis
- Sclerosis
- Severity of Illness Index
- Young Adult
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