Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Viscum articulatum Burm. is used traditionally in Chinese medicine for treating hypertension. AIM OF THE STUDY: MATERIALS AND METHODS: Six groups of rats were investigated for 4 weeks as normal control, L-NAME (40 mg/kg/day), L-NAME+enalapril (15 mg/kg/day), L-NAME+L- arginine (100 mg/kg/day), L-NAME+MVA (200 mg/kg/day) and L-NAME+MVA (400 mg/kg/day) for four weeks. The systolic blood pressure (SBP) and heart rate (HR) were measured weekly throughout the experimental period. The urine electrolytes concentration, cardiac mass index, serum nitrate/ nitrite (NO(x)) level, serum creatinine level and lipid profile were determined. RESULTS: Treatment with MVA (200 and 400 mg/kg) or enalapril delayed the rise in SBP produced by administration of L-NAME. None of the treatments had a significant effect on the depression of the serum NO(x) level caused by L-NAME. The serum creatinine and total cholesterol concentrations were elevated upon administration of L-NAME, and this elevation was prevented by MVA co-administration. The urine volume and urine potassium ion level were depressed by L-NAME administration and this effect being inhibited in MVA and enalapril groups. There was no cardiac hypertrophy and HR change after 28 day of L-NAME administration. CONCLUSION: We conclude that MVA may have an antihypertensive effect in the NO deficient type of hypertension, which may be attributed to its diuretic, nephroprotective and hypolipidemic actions.
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Authors | Sagar S Bachhav, Mukesh S Bhutada, Savita D Patil, Bhavana Baser, Kishor B Chaudhari |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 142
Issue 2
Pg. 467-73
(Jul 13 2012)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 22626924
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Antihypertensive Agents
- Drugs, Chinese Herbal
- Renal Agents
- Nitric Oxide
- Enalapril
- Cholesterol
- Creatinine
- Potassium
- NG-Nitroarginine Methyl Ester
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Topics |
- Animals
- Antihypertensive Agents
(pharmacology, therapeutic use)
- Blood Pressure
(drug effects)
- Cholesterol
(blood)
- Creatinine
(blood)
- Drugs, Chinese Herbal
(pharmacology, therapeutic use)
- Enalapril
(pharmacology, therapeutic use)
- Hypertension
(blood, drug therapy, urine)
- Kidney Diseases
(blood, drug therapy, urine)
- Male
- NG-Nitroarginine Methyl Ester
- Nitric Oxide
(blood)
- Phytotherapy
- Potassium
(urine)
- Rats
- Rats, Wistar
- Renal Agents
(pharmacology, therapeutic use)
- Urination
(drug effects)
- Viscum
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