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Effect of Viscum articulatum Burm. (Loranthaceae) in Nω-nitro-L-arginine methyl ester induced hypertension and renal dysfunction.

AbstractETHNOPHARMACOLOGICAL RELEVANCE:
Viscum articulatum Burm. is used traditionally in Chinese medicine for treating hypertension.
AIM OF THE STUDY:
The present study was designed to evaluate the antihypertensive activity of the methanolic extract of Viscum articulatum (MVA) against N(ω)-nitro-L-arginine methyl ester (L-NAME) induced hypertension in rats.
MATERIALS AND METHODS:
Six groups of rats were investigated for 4 weeks as normal control, L-NAME (40 mg/kg/day), L-NAME+enalapril (15 mg/kg/day), L-NAME+L-arginine (100 mg/kg/day), L-NAME+MVA (200 mg/kg/day) and L-NAME+MVA (400 mg/kg/day) for four weeks. The systolic blood pressure (SBP) and heart rate (HR) were measured weekly throughout the experimental period. The urine electrolytes concentration, cardiac mass index, serum nitrate/nitrite (NO(x)) level, serum creatinine level and lipid profile were determined.
RESULTS:
Treatment with MVA (200 and 400 mg/kg) or enalapril delayed the rise in SBP produced by administration of L-NAME. None of the treatments had a significant effect on the depression of the serum NO(x) level caused by L-NAME. The serum creatinine and total cholesterol concentrations were elevated upon administration of L-NAME, and this elevation was prevented by MVA co-administration. The urine volume and urine potassium ion level were depressed by L-NAME administration and this effect being inhibited in MVA and enalapril groups. There was no cardiac hypertrophy and HR change after 28 day of L-NAME administration.
CONCLUSION:
We conclude that MVA may have an antihypertensive effect in the NO deficient type of hypertension, which may be attributed to its diuretic, nephroprotective and hypolipidemic actions.
AuthorsSagar S Bachhav, Mukesh S Bhutada, Savita D Patil, Bhavana Baser, Kishor B Chaudhari
JournalJournal of ethnopharmacology (J Ethnopharmacol) Vol. 142 Issue 2 Pg. 467-73 (Jul 13 2012) ISSN: 1872-7573 [Electronic] Ireland
PMID22626924 (Publication Type: Journal Article)
CopyrightCopyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Antihypertensive Agents
  • Drugs, Chinese Herbal
  • Renal Agents
  • Nitric Oxide
  • Enalapril
  • Cholesterol
  • Creatinine
  • Potassium
  • NG-Nitroarginine Methyl Ester
Topics
  • Animals
  • Antihypertensive Agents (pharmacology, therapeutic use)
  • Blood Pressure (drug effects)
  • Cholesterol (blood)
  • Creatinine (blood)
  • Drugs, Chinese Herbal (pharmacology, therapeutic use)
  • Enalapril (pharmacology, therapeutic use)
  • Hypertension (blood, drug therapy, urine)
  • Kidney Diseases (blood, drug therapy, urine)
  • Male
  • NG-Nitroarginine Methyl Ester
  • Nitric Oxide (blood)
  • Phytotherapy
  • Potassium (urine)
  • Rats
  • Rats, Wistar
  • Renal Agents (pharmacology, therapeutic use)
  • Urination (drug effects)
  • Viscum

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