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Prevalence of hepatitis B virus infection among tuberculosis patients with or without HIV in Goiânia City, Brazil.

AbstractBACKGROUND:
Hepatitis B virus (HBV) and tuberculosis (TB) represent major public health problems. There is currently little data on HBV infection among TB patients with and without human immunodeficiency virus (HIV).
OBJECTIVES:
To assess HBV prevalence among TB patients with and without HIV.
STUDY DESIGN:
From April 2008 to March 2010, a cross-sectional study was conduct among TB patients attended at a reference hospital in Goiânia City, Brazil. The participants were tested for serological markers of HBV infection and HIV antibodies. HBV DNA was detected in HBsAg-positive samples, and also in HBsAg-negative/anti-HBc-positive samples to look for HBV occult infection.
RESULTS:
Of 425 patients, 402 (94.6%) agreed to participate in the study. The overall prevalence of HBV (HBsAg and/or anti-HBc positive) and HIV infections were 25.6% (103/402) and 27.6% (111/402), respectively. A higher HBV infection rate was found among HIV-infected patients (36.9%; 41/111) compared to patients infected with TB only (20.0%; 57/285). A multivariate analysis of risk factors showed that age ≥ 50 years (p=0.03), non-injecting (p<0.01) and injecting (p<0.01) drugs use were associated with HBV infection. Among the HBsAg-positive samples (n=13), HBV DNA was detected in 10 (76.9%) samples. Of the 90 anti-HBc-positive samples, 13 were HBV DNA positive (with very low levels) resulting in an occult HBV infection rate of 14.4%. PCR-RFLP was successfully performed in 20 HBV DNA-positive samples: 15 were genotype A and 5 were genotype D.
CONCLUSIONS:
HBV infection was common, particularly among this with HIV infection.
AuthorsR S Aires, M A D Matos, C L R Lopes, S A Teles, A G Kozlowski, A M C Silva, J A A Filho, B V Lago, F C A Mello, R M B Martins
JournalJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology (J Clin Virol) Vol. 54 Issue 4 Pg. 327-31 (Aug 2012) ISSN: 1873-5967 [Electronic] Netherlands
PMID22608842 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier B.V. All rights reserved.
Chemical References
  • DNA, Viral
  • Hepatitis B Surface Antigens
Topics
  • AIDS-Related Opportunistic Infections (epidemiology)
  • Adult
  • Brazil (epidemiology)
  • Cross-Sectional Studies
  • DNA, Viral (blood)
  • Female
  • HIV Infections (complications, epidemiology)
  • HIV-1 (immunology)
  • Hepatitis B (complications, epidemiology, virology)
  • Hepatitis B Surface Antigens (blood)
  • Hepatitis B virus (classification, genetics)
  • Humans
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Prevalence
  • Risk Factors
  • Tuberculosis (complications, epidemiology, microbiology)
  • Young Adult

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