Abstract | BACKGROUND: Hepatitis B virus (HBV) and tuberculosis (TB) represent major public health problems. There is currently little data on HBV infection among TB patients with and without human immunodeficiency virus (HIV). OBJECTIVES: To assess HBV prevalence among TB patients with and without HIV. STUDY DESIGN: From April 2008 to March 2010, a cross-sectional study was conduct among TB patients attended at a reference hospital in Goiânia City, Brazil. The participants were tested for serological markers of HBV infection and HIV antibodies. HBV DNA was detected in HBsAg-positive samples, and also in HBsAg-negative/anti-HBc-positive samples to look for HBV occult infection. RESULTS: Of 425 patients, 402 (94.6%) agreed to participate in the study. The overall prevalence of HBV ( HBsAg and/or anti-HBc positive) and HIV infections were 25.6% (103/402) and 27.6% (111/402), respectively. A higher HBV infection rate was found among HIV-infected patients (36.9%; 41/111) compared to patients infected with TB only (20.0%; 57/285). A multivariate analysis of risk factors showed that age ≥ 50 years (p=0.03), non-injecting (p<0.01) and injecting (p<0.01) drugs use were associated with HBV infection. Among the HBsAg-positive samples (n=13), HBV DNA was detected in 10 (76.9%) samples. Of the 90 anti-HBc-positive samples, 13 were HBV DNA positive (with very low levels) resulting in an occult HBV infection rate of 14.4%. PCR-RFLP was successfully performed in 20 HBV DNA-positive samples: 15 were genotype A and 5 were genotype D. CONCLUSIONS:
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Authors | R S Aires, M A D Matos, C L R Lopes, S A Teles, A G Kozlowski, A M C Silva, J A A Filho, B V Lago, F C A Mello, R M B Martins |
Journal | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
(J Clin Virol)
Vol. 54
Issue 4
Pg. 327-31
(Aug 2012)
ISSN: 1873-5967 [Electronic] Netherlands |
PMID | 22608842
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier B.V. All rights reserved. |
Chemical References |
- DNA, Viral
- Hepatitis B Surface Antigens
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Topics |
- AIDS-Related Opportunistic Infections
(epidemiology)
- Adult
- Brazil
(epidemiology)
- Cross-Sectional Studies
- DNA, Viral
(blood)
- Female
- HIV Infections
(complications, epidemiology)
- HIV-1
(immunology)
- Hepatitis B
(complications, epidemiology, virology)
- Hepatitis B Surface Antigens
(blood)
- Hepatitis B virus
(classification, genetics)
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Prevalence
- Risk Factors
- Tuberculosis
(complications, epidemiology, microbiology)
- Young Adult
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