[Tumor marker--screening for gynecological cancer; personal experience. Utility of tumor markers in screening of ovarian cancer].

Abstract

PAP smears and biopsies are very effective in mass screening for uterine cancer. However, in this study, we tried to determine whether tumor markers could be useful for ovarian cancer screening. Eight tumor markers (CA125, TPA, CEA, ALP, amylase, LDH, CRP, IAP) were tested in serum samples from 3,540 women and the values were supplied to a CAMPAS (computer aided multivariate and pattern analysis system). Using this system, we managed to reduce the false positive rate to 0.68% but we couldn't prove the sensitivity of this system, because there were no ovarian cancer cases in this group. At this time, it is important to determine the high risk group of ovarian cancer for reducing the cost of mass screening. Finally, if tumor markers are to become more effective for ovarian cancer screening, it will be necessary to find ones that are more sensitive to ovarian cancer.

• Authors: E Kimura, S Kobayashi, Y Terashima
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 17 Issue 12 Pg. 2443-50 (Dec 1990) ISSN: 0385-0684 [Print] Japan
• PMID: 2260879 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor

Topics

• Antigens, Tumor-Associated, Carbohydrate (analysis)
• Biomarkers, Tumor (blood)
• False Positive Reactions
• Female
• Humans
• Middle Aged
• Multivariate Analysis
• Ovarian Neoplasms (diagnosis)
• Sensitivity and Specificity