JAK2 V617F down-modulates MPL.

Abstract

Decreased expression of the thrombopoietin receptor (TPOR or MPL) on the cell surface of platelets and megakaryocytes is an established feature of and myelofibrosis; however, the exact mechanism responsible for this phenomenon has gone largely unexplained. In this issue of Blood, Pecquet and colleagues publish an excellent study revealing that MPL expression is downregulated in the context of the mutant protein, JAK2V617F.

• Authors: Angela G Fleischman, Jeffrey W Tyner
• Journal: Blood (Blood) Vol. 119 Issue 20 Pg. 4579-80 (May 17 2012) ISSN: 1528-0020 [Electronic] United States
• PMID: 22596167 (Publication Type: Comment, Journal Article)