The antidepressant agomelatine in daily practice: results of the non-interventional study VIVALDI.

Abstract

The non-interventional study VIVALDI was carried out to evaluate the treatment with agomelatine, an innovative antidepressant, in routine practice.665 psychiatrists treated 3 317 patients over 12 weeks with agomelatine and documented antidepressant effects via svMADRS, CGI scale and CircScreen questionnaire. Subgroups with severe depression (svMADRS ≥30) and elderly patients (≥65 years) were also analyzed.In the total population, svMADRS total score decreased from 30.6 at baseline to 12.8 at final visit, in severely depressed patients from 36.7 to 14.7, in elderly patients from 29.0 to 12.2. In total 65.8% of patients could be classified as responders (≥50% decrease in svMADRS total score) and 54.8% as remitters (svMADRS ≤12). Daytime sleepiness was ameliorated in 78.2% of patients. Adverse drug reactions were reported for 10.0%, 8.9% and 10.1% of patients in total population, severely ill and elderly patients, respectively.In this study, the antidepressant effects, improvement of circadian rhythm disorders and good tolerability of agomelatine were observed in unselected depressed patients, including multimorbid elderly and severely depressed patients under routine practice.

• Authors: G Laux, VIVALDI Study Group
• Journal: Pharmacopsychiatry (Pharmacopsychiatry) Vol. 45 Issue 7 Pg. 284-91 (Nov 2012) ISSN: 1439-0795 [Electronic] Germany
• PMID: 22592503 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Acetamides
• Antidepressive Agents
• agomelatine
• Aspartate Aminotransferases
• Alanine Transaminase

Topics

• Acetamides (adverse effects, therapeutic use)
• Adolescent
• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Alanine Transaminase (metabolism)
• Antidepressive Agents (adverse effects, therapeutic use)
• Aspartate Aminotransferases (metabolism)
• Depressive Disorder, Major (blood, complications, drug therapy)
• Female
• Humans
• Male
• Middle Aged
• Private Practice
• Psychiatric Status Rating Scales (statistics & numerical data)
• Sleep Disorders, Circadian Rhythm (blood, complications, drug therapy)