HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Impact on wound healing and efficacy of various leg ulcer debridement techniques.

AbstractAIM:
To evaluate the evidence on the impact of different debridement techniques on healing and their efficacy in the treatment of leg ulcers.
METHODS:
Web-based search (PubMed) for trials investigating surgical, enzymatic, autolytic, osmotic, ultrasound-assisted, and biosurgical wound debridement on leg ulcers with regard to healing and efficacy.
RESULTS:
Both surgical and hydrosurgical methods proved to be effective debridement techniques. For conventional surgical debridement, a significantly greater reduction of the wound surface area and a higher healing rate were reported. Studies on autolytic, osmotic, and enzymatic wound debridement showed effective debridement for krill enzymes, dextranomer and manuka honey. Only for manuka honey was there a significantly greater reduction of the wound surface area compared to standard treatment. One study comparing fibrinolysin/DNAse with placebo and one comparing autolytic with enzymatic debridement showed no significant differences between the respective techniques. Trials on ultrasound-assisted wound debridement reported a positive impact on healing. A significant wound surface area reduction was demonstrated in one of them. Maggot therapy led to effective debridement. The largest trial showed no significantly improved healing.
CONCLUSIONS:
Further studies are needed to strengthen the evidence for a significant impact of wound debridement on the healing of leg ulcers.
AuthorsMartin Doerler, Stefanie Reich-Schupke, Peter Altmeyer, Markus Stücker
JournalJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG (J Dtsch Dermatol Ges) Vol. 10 Issue 9 Pg. 624-32 (Sep 2012) ISSN: 1610-0387 [Electronic] Germany
PMID22591415 (Publication Type: Editorial, Meta-Analysis, Review)
Copyright© The Authors • Journal compilation © Blackwell Verlag GmbH, Berlin.
Topics
  • Debridement (statistics & numerical data)
  • Dermatologic Surgical Procedures (statistics & numerical data)
  • Humans
  • Leg Ulcer (epidemiology, surgery)
  • Postoperative Complications (epidemiology, prevention & control)
  • Prevalence
  • Treatment Outcome
  • Wound Healing

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: