Abstract | BACKGROUND: METHODS: KEY RESULTS: Three patients (14%) with chagasic GI dysmotility were found to have positive anti-VGKC antibody titers. No antibodies were detected in patients with idiopathic GINMD. The VGKCs were found in enteric neurons at every level of the gut in unique yet overlapping distributions. The VGKC expression in GI smooth muscle was found to be limited to the esophagus. CONCLUSIONS & INFERENCES: A small proportion of patients with GI dysfunction secondary to Chagas' disease have antibodies against VGKCs. The presence of these channels in the human enteric nervous system may have pathological relevance to the growing number of GINMDs with which anti-VGKC antibodies have been associated.
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Authors | A W Hubball, B Lang, M A N Souza, O D Curran, J E Martin, C H Knowles |
Journal | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
(Neurogastroenterol Motil)
Vol. 24
Issue 8
Pg. 719-28, e344
(Aug 2012)
ISSN: 1365-2982 [Electronic] England |
PMID | 22591165
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 Blackwell Publishing Ltd. |
Chemical References |
- Autoantibodies
- Autoantigens
- Shaker Superfamily of Potassium Channels
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Autoantibodies
(blood, immunology)
- Autoantigens
(immunology)
- Chagas Disease
(complications, immunology)
- Digestive System Diseases
(etiology, immunology)
- Female
- Gastrointestinal Motility
- Humans
- Immunohistochemistry
- Immunoprecipitation
- Male
- Middle Aged
- Shaker Superfamily of Potassium Channels
(immunology)
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