HLA-DRB1*1501 and HLA-DQB1*0301 alleles are positively associated with HPV16 infection-related Kazakh esophageal squamous cell carcinoma in Xinjiang China.

HLA-DRB11501 and HLA-DQB10301 alleles are positively associated with HPV16 infection-related Kazakh esophageal squamous cell carcinoma in Xinjiang China.

Abstract	Multiple determinant factors are involved in the occurrence and progression of esophageal squamous cell carcinoma (ESCC). Human papillomavirus (HPV) and human leukocyte antigen (HLA) polymorphism were identified as important factors. This study examined the associations between the development of Kazakh ESCC and the determinant factors including HLA-DRB10901, 1501; DQB10301, 0602; high-risk HPV infection in the area of Xinjiang, China. 200 Kazakh patients with ESCC and 150 controls were recruited, and polymerase chain reaction (PCR) was performed to detect HLA-DRB10901, 1501 and DQB10301,0602 using sequence-specific primers (SSPs). HPV16 was detected in esophageal specimens using PCR. HPV16 infection rate in Kazakh ESCC case group was 41 %, significantly higher than that of control group 14 % (OR = 3.62; 95 % CI, 2.15-6.09; P < 0.001). A positive association between ESCC and HLA-DRB11501 (OR = 2.46, P < 0.0125) or HLA-DQB10301 (OR = 3.34, P < 0.0125) alleles was observed. Similar tendencies were observed for HLA-DRB11501 (OR = 3.095, P < 0.0125) and HLA-DQB10301 (OR = 2.410, P < 0.0125) alleles with HPV16-positive ESCC. HLA-DRB11501, HLA-DQB10301 and DQB10602 were significantly associated with ESCC when the age was ≥55 years (P < 0.0125 for all), whereas only HLA-DQB10301 was significantly associated with ESCC when the age was <55 years (P < 0.0125). HLA-DRB11501 and HLA-DQB10301 were significantly associated with an increase in ESCC occurrence in females (P < 0.0125), whereas only HLA-DQB10301 was significantly associated with ESCC in males. Moreover, the occurrence of HLA-DQB10602 gene in poorly differentiated ESCC group (68.8 %) was slightly higher than that of well-differentiated squamous cell carcinoma group (31.2 %). The difference was not statistically significant (P > 0.0125). The study suggests that HLA-DRB11501 and HLA-DQB10301 may influence the immune response to specific tumor and HPV-encoded epitopes and affect the risk of Kazakh ESCC in XinJiang, China.
Authors	Jianming Hu, Ling Li, Lijuan Pang, Yunzhao Chen, Lan Yang, Chunxia Liu, Jin Zhao, Bing Chang, Yan Qi, Weihua Liang, Feng Li
Journal	Cancer immunology, immunotherapy : CII (Cancer Immunol Immunother) Vol. 61 Issue 11 Pg. 2135-41 (Nov 2012) ISSN: 1432-0851 [Electronic] Germany
PMID	22588649 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	HLA-DQ beta-Chains HLA-DQB1 antigen HLA-DRB1 Chains HLA-DRB1*15:01 antigen
Topics	Adult Aged Carcinoma, Squamous Cell (epidemiology, genetics, virology) China (epidemiology) Esophageal Neoplasms (epidemiology, genetics, virology) Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease HLA-DQ beta-Chains (genetics) HLA-DRB1 Chains (genetics) Human papillomavirus 16 (isolation & purification) Humans Incidence Kazakhstan (ethnology) Male Middle Aged Papillomavirus Infections (complications, epidemiology) Polymorphism, Genetic

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