Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence.

Abstract

BACKGROUND:

Postprandial hyperlipidemia partially refers to the postprandial accumulation of chylomicrons and chylomicron remnants (CM-R). Many in vitro studies have shown that CM-R has highly atherogenic properties, but consensus is lacking on whether CM-R accumulation correlates with the development of atherosclerotic cardiovascular diseases. We investigated the correlation between CM-R accumulation and the prevalence of coronary artery disease (CAD).

DESIGN:

Subjects who received a coronary angiography and did not take any lipid-lowering drugs (n = 189) were enrolled. Subjects with coronary artery stenosis (≥ 75%) were diagnosed as CAD. Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B-48 concentration were compared between CAD patients (n = 96) and age-, sex-, and body mass index (BMI)-matched non-CAD subjects without overt coronary stenosis (< 75%) (n = 67). We tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B-48 and other coronary risk factors (high triglyceride, low HDL-C, high HbA1c or low adiponectin levels) increased the prevalence of CAD.

RESULTS:

Fasting serum apo B-48 levels were significantly higher in CAD patients than in non-CAD subjects (3·9 ± 2·4 vs. 6·9 ± 2·6 μg/mL, P < 0·0001) and had the most significant correlation with the existence of CAD. The clustering of high fasting apo B-48 levels (> 4·34 μg/mL, the cut-off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B-48 levels.

CONCLUSION:

Fasting serum apo B-48 levels significantly correlated with the prevalence of CAD.

• Authors: Daisaku Masuda, Taizo Sugimoto, Ken-Ichi Tsujii, Miwako Inagaki, Kazuhiro Nakatani, Miyako Yuasa-Kawase, Kazumi Tsubakio-Yamamoto, Tohru Ohama, Makoto Nishida, Masato Ishigami, Toshiharu Kawamoto, Akifumi Matsuyama, Naohiko Sakai, Issei Komuro, Shizuya Yamashita
• Journal: European journal of clinical investigation (Eur J Clin Invest) Vol. 42 Issue 9 Pg. 992-9 (Sep 2012) ISSN: 1365-2362 [Electronic] England
• PMID: 22587365 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 The Authors. European Journal of Clinical Investigation © 2012 Stichting European Society for Clinical Investigation Journal Foundation.

Chemical References

• Apolipoprotein B-48
• Lipids

Topics

• Aged
• Apolipoprotein B-48 (blood)
• Coronary Artery Disease (blood, physiopathology)
• Fasting
• Female
• Humans
• Hyperglycemia (blood)
• Lipids (blood)
• Male
• Middle Aged
• Postprandial Period
• Prevalence
• Risk Factors
• Statistics as Topic