A new target for therapy in squamous cell carcinoma of the lung.

Abstract	Investigators report the identification of novel somatic mutations in the DDR2 kinase gene in squamous cell carcinoma of the lung. Cellular, biochemical, and human data suggest that tumor cells harboring DDR2 mutations have increased sensitivity to existing tyrosine kinase inhibitors, providing rationale for clinical trials of agents that inhibit DDR2 kinase in the disease.
Authors	Kadoaki Ohashi, William Pao
Journal	Cancer discovery (Cancer Discov) Vol. 1 Issue 1 Pg. 23-4 (Jun 2011) ISSN: 2159-8290 [Electronic] United States
PMID	22586316 (Publication Type: Journal Article, Comment)
Chemical References	Receptors, Mitogen Discoidin Domain Receptors Receptor Protein-Tyrosine Kinases
Topics	Animals Carcinoma, Non-Small-Cell Lung (drug therapy, genetics) Discoidin Domain Receptors Humans Lung Neoplasms (drug therapy, genetics) Receptor Protein-Tyrosine Kinases (genetics) Receptors, Mitogen (genetics)

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