Abstract |
Twenty years after its original discovery, tenofovir has acquired a crucial position in the fight against human immunodeficiency virus (HIV). First, tenofovir disoproxil fumarate (TDF) is not only efficacious against, and has been licensed for the treatment of HIV ( AIDS), but also HBV ( hepatitis B). Second, for the treatment of HIV infections, TDF can be used in combination with other anti-HIV drugs, such as emtricitabine (combination termed Truvada(®)) and Truvada can be further combined with efavirenz, rilpivirine, elvitegravir, atazanavir, or darunavir, as a single once-daily oral pill. Third, Truvada can be used prophylactically to prevent transmission of HIV infection. And fourth, to prevent sexual HIV transmission, tenofovir could also be used topically (i.e., as a vaginal gel).
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Authors | Erik De Clercq |
Journal | Medicinal research reviews
(Med Res Rev)
Vol. 32
Issue 4
Pg. 765-85
(Jul 2012)
ISSN: 1098-1128 [Electronic] United States |
PMID | 22581627
(Publication Type: Journal Article, Review)
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Copyright | © 2012 Wiley Periodicals, Inc. |
Chemical References |
- Anti-HIV Agents
- Drug Combinations
- Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
- Organophosphonates
- Organophosphorus Compounds
- Deoxycytidine
- Tenofovir
- Adenine
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Topics |
- Adenine
(analogs & derivatives, therapeutic use)
- Anti-HIV Agents
(therapeutic use)
- Deoxycytidine
(analogs & derivatives, therapeutic use)
- Drug Combinations
- Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
- HIV
(drug effects)
- HIV Infections
(drug therapy, prevention & control)
- Humans
- Organophosphonates
(therapeutic use)
- Organophosphorus Compounds
(therapeutic use)
- Tenofovir
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