Control of in vivo blood clearance time of polymeric micelle by stereochemistry of amphiphilic polydepsipeptides.

Abstract

Polymeric micelle, "Lactosome", is composed of amphiphilic polydepsipeptide with a hydrophobic block of helical poly(L-lactic acid) (PLLA) and a hydrophilic block of poly(sarcosine). Lactosome was labeled by incorporation of poly(lactic acid) having a near-infrared fluorescence (NIRF) chromophore, and studied on blood clearance and tumor imaging. In vivo blood clearance time of Lactosome was prolonged with incorporation of poly(D-lactic acid) (PDLA), but decreased with poly(D,L-lactic acid) (PDLLA). NIRF imaging with applying these Lactosomes to tumor-bearing mice revealed that the tumor/background intensity ratio increased with incorporation of PDLLA. Stereochemistry in the hydrophobic core of self-assemblies is thus an important factor for determining physical stability in the blood stream and consequently contrast in imaging.

• Authors: Akira Makino, Eri Hara, Isao Hara, Ryo Yamahara, Kensuke Kurihara, Eiichi Ozeki, Fumihiko Yamamoto, Shunsaku Kimura
• Journal: Journal of controlled release : official journal of the Controlled Release Society (J Control Release) Vol. 161 Issue 3 Pg. 821-5 (Aug 10 2012) ISSN: 1873-4995 [Electronic] Netherlands
• PMID: 22580110 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2012 Elsevier B.V. All rights reserved.

Chemical References

• Depsipeptides
• Fluorescent Dyes
• Micelles
• Peptides
• Polyesters
• Polymers
• polysarcosine
• Lactic Acid
• poly(lactide)
• Indocyanine Green
• Sarcosine

Topics

• Animals
• Cell Line
• Depsipeptides (administration & dosage, blood, chemistry)
• Fluorescent Dyes (administration & dosage, analysis, chemistry)
• Humans
• Indocyanine Green (administration & dosage, analysis, chemistry)
• Lactic Acid (administration & dosage, blood, chemistry)
• Mice
• Mice, Nude
• Micelles
• Neoplasms (metabolism)
• Peptides (administration & dosage, blood, chemistry)
• Polyesters
• Polymers (administration & dosage, chemistry)
• Sarcosine (administration & dosage, analogs & derivatives, blood, chemistry)
• Stereoisomerism