Metabolic acidosis during treatment of mushroom poisoning: a diagnostic pitfall.

Abstract

Metabolic acidosis is a frequently encountered acid-base disturbance in hospitalized patients that occasionally develops in the course of treatment with medications used in everyday clinical practice, including propylene glycol-containing drugs (lorazepam, diazepam, etomidate, pentobarbital). Disruption of enterohepatic circulation with activated charcoal is a common practice for several intoxications, including mushroom poisoning. Herein, we present a patient who was hospitalized due to mushroom intoxication and developed severe metabolic acidosis as a treatment side effect rather than from the mushroom poisoning. To the best of our knowledge, this is the first report on propylene glycol-containing activated charcoal-induced metabolic acidosis.

• Authors: Nikolaos K Gatselis, George Liamis, Konstantinos P Makaritsis, George N Dalekos
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 51 Issue 9 Pg. 1077-80 ( 2012) ISSN: 1349-7235 [Electronic] Japan
• PMID: 22576391 (Publication Type: Case Reports, Journal Article)

Chemical References

• Silymarin
• Charcoal
• Silybin

Topics

• Acidosis (chemically induced, diagnosis)
• Aged
• Charcoal (adverse effects)
• Female
• Humans
• Mushroom Poisoning (diagnosis, drug therapy)
• Silybin
• Silymarin (adverse effects)
• Treatment Outcome